Biochemical study on the effects of silver nanoparticles on male albino rats

Gad, Emad; Rashad, Badwia; Hamza, Mohamed

doi:10.21608/aels.2022.156703.1018

Biochemical study on the effects of silver nanoparticles on male albino rats

Document Type : Original research articles

Authors

¹ Chemistry Department, Faculty of Science, Suez Canal University, 41522 Ismailia, Egypt

² Biochemistry Department, Faculty of Veterinary Medicine, Zagazig University, 44519, Zagazig, Egypt

10.21608/aels.2022.156703.1018

Abstract

Silver nanoparticles represent a superior nano product with potential applications in medicine and hygiene because of their antibacterial effects, antiviral actions, and antifungal activity. The use of silver nanoparticles is not only restricted to medical applications but also extended to various issues related to the environment and consumer products. These particles accumulate in liver cells and lead to oxidative stress by generating reactive oxygen species. In addition, these particles decrease mitochondrial activity and cause morphological changes and toxicity. This study investigates the possible protective effect of Rutin and Morin in treating silver nanoparticle toxicity in rats’ livers. 70 White Sprague-Dawley male rats were randomly assigned to seven groups. The first group was the normal groupG1 (control); G2 (treated with Rutin 100 mg/kg body wt). G3 (treated with Morin 30 mg/kg body wt) G4 (fed with AgNPs at 125 mg/kg body wt). G5 (AgNPs + Rut). G6 (AgNPs + Mor). G7 (AgNPs + Rut + Mor). For 30 days. Venous blood was taken to obtain serum for liver function test. In (AgNPs) treated group, AST and ALT activity, total and direct bilirubin, ALP, levels were significantly increased while Alb, total protein were significantly decreased compared to the control group. Treatment with Rutin and Morin reduced serum AST, ALT, total and direct bilirubin, and ALP; increased the level of Alb and Total protein activity compared to the AgNPs group.

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