Ameliorative effect of Cinnamon Extract against induced hepatotoxicity in Male rats

Document Type : Original research articles

Authors

1 Chemistry Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt

2 Chemistry Department, Faculty of Science, Benha university, 13511, Benha, Egypt

3 Pathology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, 41522, Egypt

Abstract

Background Carbon tetrachloride (CCl4) causes oxidative stress in a variety of pathophysiological circumstances that can induce liver damage. Finding an effective antioxidant that can repair liver damage brought about by CCl4 is crucial. Aim This study investigated whether cinnamon ethanolic extract (CE) could reduce liver damage brought on by CCl4. Methods Twenty male rats were divided into four groups of five rats each; group I, the normal control: rats were fed on basal diet, group II: rats were administered CE at a dose of 0.1mg/kg b.wt daily for four weeks , Group III: rats were subjected to IP injection of CCl4 at a dose of 0.5ml/kg b.wt twice weekly for four weeks, Groups IV: rats were co-administered oral dose of CE (0.1 mg/kg daily) and IP injection of CCl4 (0.5 ml/kg twice weekly) for four weeks . Results CCl4 increased MDA, TNF-α and TNO levels and decreased SOD activity, and GSH level compared to normal group while CE decreased MDA, TNF-α, and TNO levels and improved SOD as well as GSH level comparative to the CCl4. Additionally, CCl4 caused a rise in liver enzymes levels related to the control group, CCl4 also increased TC, TG and LDL-C along with a significant decrease in HDL-C levels . Histopathological analyses of the livers revealed that CE decreased the toxicity of CCl4 and preserved the histoarchitecture of the liver tissue. Conclusions Constructed on its strong antioxidant activity and its phenolic and flavonoid contents, CE expressively reduced oxidative damage compared to CCl4 treated group.

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